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The third study showed that eight-year-old children with Down syndrome have an average developmental delay of four years, more often have emotional and behavioral problems, and have a less favorable health-related quality of life (HRQoL) compared with children from the general population.

Furthermore, Dutch children with Down syndrome have alarmingly high prevalence rates of overweight and obesity during childhood and adolescence. In the second study is observed that growth retardation in children with Down syndrome meanly occurs in three critical periods of growth, resulting in shorter final stature and smaller head circumference than the general Dutch population shows. The first study showed that the number of live births of children with Down syndrome in the Netherlands remained stable over the period 1997-2007 on 14.6 per 10,000 births. Show more In this thesis, four studies on children and adolescents with Down syndrome are described.

Growth, development and social functioning of individuals with Down syndrome Doctoral Thesis In this thesis, four studies on children and adolescents with Down syndrome are described.

Curriculum Vitae_List of publications_Afterword_Acknowledgements.

Part 4 Social functioning and behavior at adolescence.

Part 3 Development and behaviour in childhood.

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